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Cryptococcus neoformans

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Taxonomic lineage

cellular organisms - Eukaryota - Fungi/Metazoa group - Fungi - Dikarya - Basidiomycota - Agaricomycotina - Tremellomycetes - Tremellales - Tremellaceae - Filobasidiella - Filobasidiella/Cryptococcus neoformans species complex - Filobasidiella neoformans

Brief facts


Cryptococcus neoformans (Filobasidiella neoformans) life cycle

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Developmental stages

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Mating types

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Appendix 1: MATα allele enhances filamentation

Lin X, Huang JC, Mitchell TG, Heitman J. Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation. PLoS Genet. 2006 Nov 17;2(11):e187.

Fruiting in a and alpha Isolates of C. neoformans

Fruiting in a and α Isolates Is Similar The filamentous isolate B3502a was cultured on V8 medium in the presence of synthetic α pheromone at 22 °C in the dark for two wk. The filamentous edge far from the original yeast growth patch was separated, fixed, and stained with DAPI. (A) The hyphae produced are monokaryotic with unfused clamps. (B) Four long chains of basidiospores were produced during fruiting. (C) Basidia with one, two, or four nuclei at different stages of basidium development were observed. In (A) and (C), the upper panel shows the DIC images, and the lower panel shows the corresponding fluorescent images. Scale bar, 10 μm.

Variation in Filamentous Growth of C. neoformans during Fruiting

Variation in Filamentous Growth during Fruiting A subset of the fruiting progeny derived from the cross between the nonfilamentous strain B3501α and the filamentous strain B3502a was examined microscopically. Cells were cultured on V8 medium for 25 d. Parental strains and several representative progeny displaying variations in hyphal growth are shown with the strain names listed below them.

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Appendix 2: cryptococcosis of the lung

Perfect JR. Management of cryptococcosis: how are we doing? PLoS Med. 2007 Feb;4(2):e47.

Cryptococcosis of the Lung in a Patient with AIDS

Cryptococcosis of the Lung in a Patient with AIDS Histopathology of lung shows widened alveolar septa containing a few inflammatory cells and numerous yeasts of the fungal pathogen C. neoformans. The inner layer of the yeast capsule stains red. Cryptococcosis is transmitted through inhalation of airborne yeast cells and/or biospores. At risk are the immunocompromised, especially those with HIV infection. Photo: CDC/Dr. Edwin P. Ewing, Jr.

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